金黄色葡萄球菌ESAT-6分泌系统研究进展
网络出版日期: 2016-08-31
基金资助
国家自然科学基金(81322025,81371875);上海曙光人才计划(12SG03);上海市科学技术委员会基金(14140901000,15411960500);上海市教育委员会高峰高原学科建设计划(20152513)
Research advances in ESAT-6 secretion system in Staphylococcus aureus
Online published: 2016-08-31
Supported by
National Natural Science Foundation of China, 81322025, 81371875; Shanghai Shuguang Talent Project, 12SG03; Foundation of Shanghai Municipal Science and Technology Committee, 14140901000, 15411960500; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152513
金黄色葡萄球菌是临床重要的致病菌,引起的感染可以累及全身各脏器,严重威胁人类健康。ESAT-6分泌系统广泛存在于革兰阳性菌。在金黄色葡萄球菌中,经典的ESAT-6通路由esxA、esxB及其他9个分子组成的基因簇构成,该系统分泌的ESAT-6/WXG100家族蛋白对金黄色葡萄球菌的毒力和免疫防御功能起到重要作用。该文就金黄色葡萄球菌ESAT-6分泌系统的研究进展进行综述。
关键词: 金黄色葡萄球菌; ESAT-6分泌系统; 毒力
王亚楠 李敏 . 金黄色葡萄球菌ESAT-6分泌系统研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(8) : 1210 . DOI: 10.3969/j.issn.1674-8115.2016.08.020
Staphylococcus aureus is an important opportunistic pathogen that causes a variety of infections, which can involve all organs in the body and seriously threat people’s health. The ESAT-6 secretion system widely exists in gram-positive bacteria. Typical ESAT-6 pathway is composed of a gene cluster consisting of esxA, esxB, and nine other molecules in Staphylococcus aureus. ESAT-6/WXG100 protein family secreted by this system plays a critical role in virulence and protective immunity of Staphylococcus aureus. This article reviews research advances in ESAT-6 secretion system in Staphylococcus aureus.
Key words: Staphylococcus aureus; ESAT-6 secretion system; virulence
/
〈 |
|
〉 |