网络出版日期: 2016-11-29
基金资助
国家自然科学基金(81101442)
Research progresses of the correlation between Rho/Rock signaling pathway and pulmonary fibrosis
Online published: 2016-11-29
Supported by
National Natural Science Foundation of China, 81101442
漆秀洁 , 李静 , 谭利平 , 许峰 , 方芳 . Rho/Rock信号通路与肺纤维化相关性的研究进展[J]. 上海交通大学学报(医学版), 2016 , 36(10) : 1533 . DOI: 10.3969/j.issn.1674-8115.2016.10.028
Rho/Rock signaling pathway is a key signaling pathway regulating cell proliferation and tissue differentiation, as well as a signal transduction pathway moderating stem cell self-renewal process. Under the stimulation of a various inflammatory cytokines, Rho/Rock pathway is involved in biological behaviors such as cell contraction, chemotaxis, adhesion, and invasion via kinase cascade. Rho/Rock signaling transduction pathway is closely related to pulmonary fibrosis. Therefore, deep understanding of the effects and mechanisms of Rho/Rock pathway in pulmonary fibrosis may reveal novel breaking points for prevention and treatment of pulmonary fibrosis.
Key words: Rho; Rock; pathway; pulmonary fibrosis
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