Apelin在神经系统中作用的研究进展
网络出版日期: 2017-05-31
基金资助
上海市科委科研基金(14411972000);上海交通大学“医工交叉”科研基金(YG2013MS23);上海交通大学医学院科研基金(
152H2013)
Research progresses of apelin in nervous system
Online published: 2017-05-31
Supported by
Science and Technology Commission of Shanghai Fund, 14411972000; Shanghai Jiao Tong University Fund for Interdisciplinary Research on Medicine and Engineering, YG2013MS23; Shanghai Jiao Tong University School of Medicine Fund, 152H2013
魏珍玉 , 吴丹红 . Apelin在神经系统中作用的研究进展[J]. 上海交通大学学报(医学版), 2017 , 37(5) : 704 . DOI: 10.3969/j.issn.1674-8115.2017.05.027
Apelin is the endogenous ligand of a G protein-coupled receptor called APJ, its propeptide is an X-linked and coded peptide with 77 amino acids. Apelin/apelin receptor system is widely distributed in the body and is involved in various physiological and pathological regulations. It has been demonstrated that apelin is associated with the occurrence and development of many diseases, including angiocardiopathy, pulmonary arterial hypertension, nephropathy, cancer, endocrine disease, and so on. Currently, studies on apelin in nervous system have been developed gradually. This article focuses on apelin and summarizes the distribution and pathophysiological roles of apelin in nervous system, as well as in the occurrence and development of diseases associated with nervous system.
Key words: apelin; nervous system; brain injury; recognition damage
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