›› 2011, Vol. 31 ›› Issue (11): 1540-.doi: 10.3969/j.issn.1674-8115.2011.11.008

• Monographic report (Bipolar disorder) • Previous Articles     Next Articles

Research progress of immunological mechanisms of bipolar disorder

HONG Wu, FANG Yi-ru   

  1. Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 81000581, 30971047;National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430;Shanghai Jiaotong University School of Medicine Foundation, 2008-6;Shanghai Mental Health Center Foundation, 2011-YJ-06


The pathogenesis of bipolar disorder has not been clearified. Heredity, neurotransmitter, neurotrophy, oxidative stress, immunology and environment have been reported to be related to the pathogenesis of bipolar disorder. Nowadays, the relationship between bipolar disorder and immunity has become the focus of attention. This review summarizes the immunity-related gene polymorphisms and cytokines in the pathogenesis of bipolar disorder, discusses the causal relationship between bipolar disorder and dysimmunity, and explore the application of immunity-related methods in the diagnosis and treatment of bipolar disorder.

Key words: bipolar disorder, immunology, cytokine