›› 2011, Vol. 31 ›› Issue (11): 1612-.doi: 10.3969/j.issn.1674-8115.2011.11.023

• Original article (Clinical research) • Previous Articles     Next Articles

Creation and application of test methods for error-monitoring function

CHEN Xing-shi1, TANG Yun-xiang2, XU Yi-feng3, WANG Ji-jun4, ZHANG Ming-dao1, LOU Fei-ying1, LIANG Jian-hua1, CHEN Chong1, YIN Guang-zhong5, ZHANG Zai-fu6   

  1. 1.Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China；2.Department of Medical Psychology, the Second Military Medical University, Shanghai 200433, China；3.Department of Psychiatry, 4.Department of Electronic Encephalography Source Imaging, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China；5.Department of Psychiatry, Suzhou Guangji Hospital, Suzhou 215008, China；6.Department of Psychiatry, Jinhua the Second Hospital, Jinhua 321016, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30971046, 30770772；National Basic Research Program of China, “973” Program, 2010CB529605

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Abstract:

Objective To investigate the features of error-monitoring function in healthy adults with event-related potentials (ERP). Methods Sixty-two righthanded healthy adults (33 males and 29 females) aged between 19 and 50 years were enrolled, with the mean age of (29.6±6.6) years and mean education experience of (16.7±2.0) years. Error-related negativity (ERN) in frontal zone (Fz), central zone (Cz), left central zone (C3), right central zone (C4) and parietal zone (Pz) was detected with ERP instrument (Brain Products, Germany), and the latencies and wave amplitudes of ERN were statistically analysed. Results A negative wave was detected in each scalp electrode about 50 ms after the stimuli presented, and the ERN waveform was stable. Statistical analysis revealed that there was no significant difference in the latencies and wave amplitudes of ERN between C3 and C4 (P>0.05). In Fz, Cz and Pz, there was no significant difference in the latencies and wave amplitudes of ERN between males and females (P>0.05). The wave amplitudes of ERN in Fz and Cz were significantly positively related to the age of subjects (r=0.282, P=0.027; r=0.250, P=0.049). Conclusion ERN is stable and reliable in healthy adults. As a clinically valuable ERP component, ERN can be used in clinical practice of department of Neurology and Psychiatry.

Key words: healthy adult, error-monitoring mechanism, event-related potentials, normal value bank