›› 2011, Vol. 31 ›› Issue (12): 1746-.doi: 10.3969/j.issn.1674-8115.2011.12.019

• Original article (Clinical research) • Previous Articles     Next Articles

Effects of budesonide suspension inhalation on relieving postoperative throat complications after tracheal intubation under general anesthesia

CHEN Yan-qing1,2, WANG Jia-dong1,2, XU Ya-nan1,2, XIAO Jie3   

  1. 1.Department of Otolaryngology-Head &|Neck Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, 2.Otolaryngology Institute of Shanghai Jiaotong University, 3.Department |of Anesthesia, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2011-12-28 Published:2012-01-04

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Abstract:

Objective To investigate the effects of budesonide suspension inhalation on relieving postoperative throat complications after tracheal intubation under general anesthesia. Methods One hundred and ten patients with benign thyroid tumors undergoing tracheal intubation under general anesthesia were randomly divided into group A (n=40, 2 mg budesonide suspension inhalation 1 h before operation and 6 h, 24 h and 48 h after operation), group B (n=40, 2 mg budesonide suspension inhalation 6 h, 24 h and 48 h after operation) and group C (n=30, inhalation of normal saline 6 h, 24 h and 48 h after operation). The conditions of throat were observed in each group after operation, and the effectiveness of different methods of suspension inhalation in signs and symptoms after tracheal intubation was evaluated in each group. Results The incidences of sore throat, cough and hoarseness after operation in all patients were 99%, 13.6% and 53.6% respectively. The scoring of sore throat at each time point after operation and hoarseness 1 h, 6 h and 24 h after operation in group A was better than that in group B （P<0.05）. There were significant differences in the scoring of sore throat and hoarseness 48 h after operation between group B and control group （P<0.05）, while there was no significant difference in the scoring of sore throat and hoarseness at the other time points between two groups （P＞0.05）. There was no significant difference in the scoring of cough among three groups （P＞0.05）. The scoring of mucosa reaction of throat 1 h, 6 h and 24 h after operation in group A was better than that in group B and control group, and the scoring of mucosa reaction of throat 6 h, 24 h and 48 h after operation in group B was better than that in control group （P<0.05）. Conclusion Inhalation of budesonide suspension is effective in reducing the throat injury caused by tracheal intubation under general anesthesia, and preoperative administration may have preventive function to some degree.

Key words: budesonide, suspension inhalation, tracheal intubation, throat complications