›› 2012, Vol. 32 ›› Issue (2): 189-.doi: 10.3969/j.issn.1674-8115.2012.02.014

• Original article (Clinical research) • Previous Articles     Next Articles

Characteristics of flash-electroretinography in patients with hyperlipidemia

ZHANG Bei, QIU Qing-hua, WANG Chuan, LI Sheng-yang   

  1. Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

Abstract:

Objective To describe the characteristics of flash-electroretinography (F-ERG) in patients with hyperlipidemia, and investigate the effect of hyperlipidemia on the retinal function. Methods One hundred and twenty-four patients with hyperlipidemia diagnosed at the First People's Hospital affiliated to Shanghai Jiaotong University between February 2011 and June 2011 were selected as hyperlipidemia group, and another 60 healthy people were served as normal control group. F-ERG was performed in both groups, and a wave and b wave of rod cell response (Rod-a and Rod-b), a wave and b wave of maximum response (Max-a and Max-b), oscillatory potentials (Ops), a wave and b wave of cone cell response (Cone-a and Cone-b) and b wave of 30 Hz flicker response (Flicker-b) were recorded. The wave amplitudes and latencies of 5 items of standard F-ERG and the ratios of wave amplitude of Max-b to that of Max-a (b/a) were compared between two groups. Results The wave amplitudes of 5 items of standard F-ERG in hyperlipidemia group were significantly lower than those in normal control group (P<0.01). The latency of Max-b wave of standard F-ERG in hyperlipidemia group was slightly longer than that in normal control group (P<0.05), and the wave latencies of the other 4 items of standard F-ERG in hyperlipidemia group were significantly longer than those in normal control group (P<0.01). The ratios of wave amplitude of Max-b to that of Max-a (b/a) in hyperlipidemia group were significantly higher than those in normal control group (P<0.01). Conclusion The retinal function of patients with hyperlipidemia is significantly impaired, and the damage in outer layer of retina is more severe than that in inner layer of retina.

Key words: hyperlipidemia, retina, electroretinography