›› 2012, Vol. 32 ›› Issue (6): 756-.doi: 10.3969/j.issn.1674-8115.2012.06.014

• Original article (Clinical research) • Previous Articles     Next Articles

Association between gallbladder disease and coronary heart atherosclerotic disease and risk factors for gallbladder disease

SUN Lu-ying1, JIANG Zhao-yan2, YANG Xiao-bo1, XU Chen-ying1, CHANG Xian-xing1, LI Wei-wei1, YU Li-fen1   

  1. 1.Department of Gastroenterology, 2.Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-06-28 Published:2012-07-02
  • Supported by:

    National Natural Science Foundation of China, 81070367

Abstract:

Objective To investigate the association between gallbladder disease (GBD) and coronary atherosclerotic heart disease (CAD), and explore the related risk factors for GBD. Methods The clinical data of patients with CAD (CAD group, n=712) and those suspected of CAD without stenosis of coronary artery (control group, n=571) confirmed by coronary angiography were retrospectively analysed. The prevalence of GBD was compared between two groups, and the association of body mass index (BMI), waist circumference, hyperlipidemia and diabetes with GBD was explored by Logistic regression analysis. Results The prevalence of GBD in CAD group was significantly higher than that in control group (37.5% vs 25.6%, P<0.01). Univariate and multivariate Logistic regression analysis revealed that CAD was significantly related to GBD for males (OR=1.32,95%CI:1.17-1.49,P<0.01), but not significantly related to GBD for females. BMI, history of hypertension, hyperlipidemia and diabetes were risk factors for GBD. Conclusion GBD is significantly related to CAD for males.

Key words: gallbladder disease, coronary atherosclerotic heart disease, hyperlipidemia, diabetes