Abstract:

It has been identified that the modification of penicillin-binding proteins (PBPs) and the reduction of affinity for β-lactams are important mechanisms by which Gram-positive cocci acquire antibiotic resistance. However, among Gram-negative bacteria,the resistance caused by the modification of PBPs has been considered unusual, which neglects the role of PBPs in β-lactams resistance in Gram-negative bacteria.In this paper, the structure, function and research method of PBPs, and the relationship between PBPs and Gram-negative bacterial resistance are reviewed.

Key words: penicillin-binding proteins, Gram-negative bacteria, resistance