Abstract:

The laminin receptor (67LR), relative molecular mass 67 000, is a non-integrin cell surface receptor for the extracellular matrix, with a higher expression in tumor cells than normal ones. The 67LR originates from 37LRP (relative molecular mass 37 000) through fatty acid acylation. It is widely involved in several processes of tumor cells, such as growth, metastasis, invasion, and apoptosis. It is not only a receptor for laminin but for several viruses and prion proteins. As the major surface receptor for epigallocatechingallate (EGCG), 67LR can coordinate with EGCG in regulation of several signal pathways and in inhibition of tumor growth and metastasis and promotion of apoptosis. The studies on mechanism of interaction between 67LR and EGCG are reviewed in this article.

Key words: 67LR, laminin receptor, epigallocatechingallate, signal pathway