Abstract:

Ageing is one of the key factors that cause many diseases. Up-to-date, most knowledge and information about the genetics of ageing in biology comes from the studies on Caenorhabditis elegans (C.elegans). The C.elegans plays an important role in the study of anti-ageing. The first aging regulation mechanism understood by the people is the DAF-2/IGF-1 signal pathway. This paper reviews the leading and promoting effects of C.elegans, which acts as a model organism, on the course of research of the DAF-2/IGF-1 signal pathways and provides helpful ideas and methods for anti-ageing studies.

Key words: Caenorhabditis elegans, ageing, DAF-2, IGF-1