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Research progresses of correlation between depression and temporomandibular disorder

YU Fei1, CHEN Si-han1, YU Qian1, LIU An-hao1, HU You-min2   

  1. 1.College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China; 2.Experiment Teaching Centre, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2014-10-28 Published:2014-10-28
  • Supported by:

    RBL Project for College Students of Shanghai Jiao Tong University School of Medicine, 2013


Depression is a common mental disease and temporomandibular disorder (TMD) is a common temporomandibular disease. The correlation of two diseases still needs further study. Hypothalamic-pituitary-adrenal (HPA) axis, serotoninergic system, tumor necrosis factor-α (TNF-α), and catechol-O-methyltransferase (COMT) gene are possible internal correlation factors of depression and TMD. The treatment of depression can relieve the symptoms of TMD to some extent. Clinicians should be aware of the coexistence of depression and TMD and conduct proper treatments. Further study should focus on the internal correlation of depression and TMD. This paper reviews research progresses of the correlation among symptoms, mechanism, and treatment of depression and TMD.

Key words: depression, temporomandibular disorder, hypothalamic-pituitary-adrenal axis, tumor necrosis factor-α