›› 2015, Vol. 35 ›› Issue (10): 1556-.doi: 10.3969/j.issn.1674-8115.2015.10.025

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Ras signaling pathway and neural plasticity mechanism of depression

WANG Fan, ZHANG Chen, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China, 91232719; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873; National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-Year Plan”, 2012BAI01B04


The pathogenesis of depression has not been clearly elucidated yet. In recent years, more and more evidences highlight the role of neural plasticity mechanism in the pathogenesis and treatment of depression. Particularly, neurotrophic factors are critical for the neural plasticity. Meanwhile the Ras signaling pathway, a vital downstream signaling pathway of the neurotrophic factor receptor, plays an important role in the neural plasticity. This paper reviews studies relevant to Ras signaling pathways and the neural plasticity mechanism of depression.

Key words: depression, Ras signaling pathways, neural plasticity, neurotrophic factors