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ACE2/Apelin signaling and atherosclerosis

ZHANG Zhen-zhou, SONG Bei, ZHONG Jiu-chang   

  1. State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Hypertension, Shanghai 200025, China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    National Major Research Plan Training Program, 91339108;  National Basic Research Program of China, 2014CB542300; National Natural Science Foundation of China, 81370362, 81170246; Scientific Research Project of Health Bureau of Shanghai, 201440368


Atherosclerotic diseases have become the leading cause of human death. The renin-angiotensin system is an important factor for promoting the occurrence and development of atherosclerotic cardiovascular diseases. Studies have revealed that the ACE2/Apelin signaling plays a protective role in the cardiovascular system. This article reviews the latest research advances in ACE2/Apelin signaling and its regulatory role in atherosclerosis.

Key words: atherosclerosis, renin-angiotensin system, angiotensin-converting enzyme 2, Apelin