›› 2019, Vol. 39 ›› Issue (10): 1204-.doi: 10.3969/j.issn.1674-8115.2019.10.018

• Review • Previous Articles     Next Articles

Immunomodulatory effect of myeloid-derived suppressor cell and its impact on tumor therapy

LI Xiao, WANG Li   

  1. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    National Natural Science Foundation of China, 81520108003, 81670716, 81830007; Project of Science and Technology Commission of Shanghai Municipality, 16JC1405800; Shanghai Outstanding Youth Medical Talents Training Funding Program; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152206; Shanghai Talent Development Fund

Abstract: Myeloid-derived suppressor cells (MDSCs) are a group of cells with potent immune suppressive activity which have emerged as an important contributor to tumor progression and genesis. More and more clinical researches have found that accumulation of MDSCs in peripheral blood and tumor tissues could predict dismal outcome for patients with malignancies, which was a potential prognostic tumor marker. In addition, immunosuppression inducedMDSCs could reduce the efficacy of anti-tumor therapies. Therefore, better understanding the mechanism of MDSCs’ immune suppression in tumor microenvironment can provide reference for exploring new immunotherapies.

Key words: myeloid-derived suppressor cell (MDSC), immunosuppression, tumor therapy

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