JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (09): 1207-1212.doi: 10.3969/j.issn.1674-8115.2020.09.007

• Original article (Clinical research) • Previous Articles     Next Articles

Analysis of the feature and influencing factors of anhedonia in schizophrenia

YU Ling-fang1, FANG Xin-yu2, CHEN Yan1, WANG Dan-dan1, WANG Ye-wei1, WU Ze-nan1, LIU Rui-mei1, ZHANG Chen1   

  1. 1. Department of Biochemistry and Pharmacology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    National Key Research and Development Program of China (2018YFC1314302); National Natural Science Foundation of China (81471358, 81771450); Western Medicine Guide Project of Shanghai Municipal Commission of Science and Technology (14411969000); Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20152530); Shanghai Municipal Commission of Health and Family Planning Foundation (201540029).

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Abstract: Objective · To explore the feature and influencing factors of anhedonia in schizophrenia. Methods · A total of 71 schizophrenia patients and 50 healthy controls were recruited during December 2018 and December 2019. Positive and Negative Syndrome Scale (PANSS) was used for assessing psychotic symptoms. Temporal Experience of Pleasure Scale (TEPS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were applied to the evaluation of anhedonia and cognitive function respectively for each subject. Results · The evaluation result of TEPS showed both anticipatory and consummatory pleasure scores were lowered in patients with schizophrenia than those in healthy people (P=0.000). Stepwise linear regression analysis showed that negative subscale score of PANSS (B=-0.895, P=0.002) and delayed memory score of RBANS (B=0.265, P=0.001) were associated with anhedonia in schizophrenia. Conclusion · Patients with schizophrenia exhibit anticipatory and consummatory anhedonia, both of which are influenced by negative symptoms and delayed memory in schizophrenia.

Key words: schizophrenia, anhedonia, negative symptom, delayed memory

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