JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (9): 1256-1260.doi: 10.3969/j.issn.1674-8115.2021.09.019

• Review • Previous Articles    

Research progress in the relationship between endosomal sorting complexes required for transport and autophagy

Yi LI(), Da-wei SUN, De-rong CUI()   

  1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2021-05-08 Online:2021-08-03 Published:2021-08-03
  • Contact: De-rong CUI;
  • Supported by:
    National Natural Science Foundation of China(81974284)


Autophagy is an intracellular degradation pathway, which can transport a large number of cytoplasmic, damaged organelles and other substrates to lysosomes for degradation to maintain intracellular homeostasis. In the process of autophagy, the integrity of autophagy flow should be ensured. Many factors affect the smooth autophagy flow, including the relationship between endosomal sorting complexes required for transport (ESCRT) and autophagy. ESCRT is mainly responsible for membrane shearing, mediating cell membrane remodeling and division, and plays an important role in the process of endocytosis and cytokinesis. In recent years, many studies have shown that ESCRT mutants generally present an accumulation of autophagosomes, suggesting that autophagy flow is affected. In-depth studies indicate that ESCRT is involved in the regulation of several processes of different types of autophagy, and its subunits also interact with autophagy-related proteins. This article reviews the related research in recent years.

Key words: autophagy, endosomal sorting complexes required for transport (ESCRT), autophagosome, endosome

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