Research progress in roles of follicular helper T cells in autoimmune diseases

doi:10.3969/j.issn.1674-8115.2022.02.013

Abstract

Abstract:

Follicular helper T cells (Tfh cells) have been defined as a new subset of CD4⁺T cells in recent years, mainly expressing surface molecules such as C-X-C motif chemokine receptor type 5, inducible co-stimulator, and secreting cytokine interleukin-21, a key transcription factor of which is B cell lymphoma 6. They exist in the germinal center (GC) of lymphoid tissue and in the peripheral blood as well. With the ability to promote B cell maturation and differentiation, GC formation and antibody production, Tfh cells play important roles in the pathogenesis of many autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and primary Sj?gren's syndrome. The abnormal quantity and/or quality of Tfh cells will cause pathological processes like tissue injury and promote disease progression. This article reviews the biological characteristics of Tfh cells and their roles in different autoimmune diseases, which may help to further reveal the pathogenesis of certain autoimmune diseases and provide a new way to treat these diseases by targeting these cells.

Key words: follicular helper T cell, autoimmune disease, B cell, autoantibody, interleukin-21

CLC Number:

R593.2

Xindi WEI, Xiaoyin NIU. Research progress in roles of follicular helper T cells in autoimmune diseases[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2022, 42(2): 218-224.

Figures/Tables 1

TrendMD

References 59

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