Reaearch progress of strategies and mechanisms of targeting bacteria based on nanoparticles

doi:10.3969/j.issn.1674-8115.2022.06.018

Abstract

Abstract:

The crisis of antibiotic resistance is one of the most pressing problems in global public health. To solve the crisis of antibiotic resistance, more and more biological nanomaterials are applied to antimicrobial in recent years. Nanoparticles (NPs) are a class of nanoscale materials with unique advantages compared with traditional antibacterial drugs. However, the application of nanoparticles still faces the dilemma of poor targeting ability and the possible damage to normal tissue. In addition to improving efficacy, targeted therapies allow us to use lower concentrations of highly toxic drugs, thereby reducing the toxic side effects on healthy tissue. Therefore, how to improve the targeting of NPs to bacteria is an important issue today. This article will give an overall introduction to nanoparticles first. Surface modification, stimuli-responsiveness and biomimetic modification of cell membrane, three common bacterial targeting strategies will be introduced later, including their basic mechanisms and the latest findings. The advantages and disadvantages of the three strategies and their future direction will also be summarized. A general picture of the developments in this field will be provided to readers, and it is hoped that new ideas for targeting bacteria will emerge in the future.

Key words: nanoparticle (NP), targeting, surface modification, stimuli-responsive, biomimetics

CLC Number:

R318.08

LUO Zhiyuan, SHI Tingwang, RUAN Zesong, CHEN Yunfeng. Reaearch progress of strategies and mechanisms of targeting bacteria based on nanoparticles[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(6): 819-824.

Figures/Tables 1

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References 53

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Category	Advantages	Disadvantages
Surface modification	High targeting efficiency，various forms	Short circulation， safety problems
Stimuli-responsive	Diverse conditions， simpler and more reproducible	Technology limitations to provide stimulus
Biomimetic modification of cell membrane	Prolonged circulation time， cell-specific targeting， detoxification	Technological complexity， lack of raw materials

Category	Advantages	Disadvantages
Surface modification	High targeting efficiency，various forms	Short circulation， safety problems
Stimuli-responsive	Diverse conditions， simpler and more reproducible	Technology limitations to provide stimulus
Biomimetic modification of cell membrane	Prolonged circulation time， cell-specific targeting， detoxification	Technological complexity， lack of raw materials

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