Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (2): 222-229.doi: 10.3969/j.issn.1674-8115.2023.02.012

• Review • Previous Articles    

Research progress in the roles of Notch signaling pathway during fracture healing

GUO Liqiang(), ZHAO Shitian, SHU Bing()   

  1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine; Spine Institute, Shanghai Academy of Traditional Chinese Medicine; Key Laboratory of Ministry of Education for Theory and Treatment of Bones and Muscles, Shanghai 200032, China
  • Received:2022-03-19 Accepted:2022-06-18 Online:2023-02-28 Published:2023-02-28
  • Contact: SHU Bing;
  • Supported by:
    National Key R&D Program of China(2018YFC1704300);National Natural Science Foundation of China(81973876);Ministry of Education Innovation Team Development Program(IRT1270);Innovation Team Project in Key Fields of Ministry of Science and Technology(2015RA4002)


Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur. The current treatment of fractures mainly pursues the completion of clinical healing and bone healing, and the healing process is divided into three stages: early, intermediate and late. Various factors affect the speed of the healing process, among which signaling pathways and cytokines play an important role in fracture healing, so understanding the important role of signaling pathways and cytokines is important for treating fractures and promoting fracture healing. Recent studies have shown that the Notch signaling pathway can affect cell proliferation and differentiation, inflammatory response, bone reconstruction, angiogenesis and nerve regeneration during fracture healing, and its changes are also closely related to mechanical stimulation and other factors. Therefore, this paper reviews the research progress in the role of Notch signaling pathway in various aspects of fracture healing from the perspectives of cell proliferation and differentiation, inflammatory response, bone reconstruction, angiogenesis, nerve regeneration and mechanical stimulation, and provides new research directions and therapeutic strategies for fracture healing treatment.

Key words: Notch, fracture healing, inflammation, mesenchymal stem cell, bone remodeling, angiogenesis, nerve regeneration

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