Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (2): 230-236.doi: 10.3969/j.issn.1674-8115.2023.02.013

• Review • Previous Articles    

Research progress of subcellular structure-targeted therapy in spinal cord injury

LIU Tiexin(), LIN Junqing, ZHENG Xianyou()   

  1. Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  • Received:2022-08-02 Accepted:2022-11-03 Online:2023-02-28 Published:2023-02-28
  • Contact: ZHENG Xianyou;
  • Supported by:
    National Natural Science Foundation of China(81974331)


Spinal cord injury is a serious disease that greatly affects the sensory function, motor function and autonomic nervous function of patients. It not only brings serious physical and mental harm to patients but also causes huge economic burden to the society. With the development of medical technology, the research on the internal mechanism of spinal cord injury is also deepening, and the treatment methods of spinal cord injury emerge in endlessly. However, the therapeutic effect is not satisfactory, so it is urgent to further explore new therapeutic strategies and expand new therapeutic ideas for spinal cord injury. Many studies have shown that various subcellular structures are closely related to nerve regeneration and functional recovery after spinal cord injury. Therefore, targeting subcellular structures to treat spinal cord injury plays an important role in promoting nerve regeneration and repair after spinal cord injury. This targeted therapy mainly refers to targeting a variety of subcellular structures such as mitochondria, lysosomes/autophagosomes, endoplasmic reticulum, intracellular bodies and proteasomes. A variety of therapeutic strategies targeting subcellular structures have significant therapeutic effects on spinal cord injury. Among them, mitochondrial targeting or endoplasmic reticulum targeting mainly focuses on maintaining mitochondrial energy metabolism at the injury site, while endoplasmic reticulum targeting mainly focuses on inhibiting endoplasmic reticulum stress. This article reviews the research progress of subcellular structure-targeted therapy in spinal cord injury, which is expected to be a new targeted therapy strategy for spinal cord injury and provide a new idea for the treatment of spinal cord injury.

Key words: spinal cord injury, subcellular structure, endoplasmic reticulum stress, mitochondrial dysfunction, targeted therapy

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