Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy
Online published: 2014-03-25
Supported by
Natural Science Foundation of Shanghai,10ZR1418500
Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor (VEGF) is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress (ERS) and hypoxia-inducible factor-1 (HIF-1) can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF.
WANG Jing , ZHU Hong , SHI Cai-hong . Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(2) : 240 . DOI: 10.3969/j.issn.1674-8115.2014.02.025
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