Correlation between microRNA-24 expression and prognosis of aflatoxin B1-related hepatocellular carcinoma prognosis
Online published: 2014-12-30
Supported by
National Natural Science Foundation of China, 81160255, 81372639, 81460423; Guangxi Natural Science Foundation, 2013GXNSFAA019251, 2014GXNSFDA118021, 2014GXNSFAA118144; “Shu Guang” Project of Shanghai, 13SG19; Innovation Program of Shanghai Municipal Education Commission, 13YZ035
Objective To explore the effects of microRNA-24 (miR-24) expression on the prognosis of aflatoxin B1 (AFB1)-related hepatocellular carcinoma (HCC). Methods A total of 207 patients with Ⅰ-Ⅱ TNM-stage HCC from high AFB1 exposure areas were selected and the corresponding surgical resection samples were collected. Expression levels of MiR-24 in the tumor tissue samples were detected by the TaqMAN-PCR technique. Cox’s regression model and logistic regression model were adopted to analyze the relationship between the miR-24 expression and the prognosis and clinicopathological features of HCC. Results Elevated expression level of miR-24 affected overall survival and tumor recurrence-free survival (P<0.01). The overall death risk and tumor recurrence risk were increased by 2.58 times and 3.75 times. This risk effect was more noticeable under high AFB1 exposure condition and the corresponding risk values were 8.13 (95%CI: 4.46-14.84) and 11.75 (95%CI: 5.15-26.79), respectively. The expression level of miR-24 was closely correlated with primary tumor size, tumor differentiation, and micro-vessel density (P<0.05), and could regulate the level of AFB1-DNA adducts. Conclusion The miR-24 expression affects the prognosis of AFB1-related HCC and regulates the clinicopathological features of HCC.
Key words: microRNA-24; hepatocellular carcinoma; aflatoxin B1; prognosis
LONG Man-mei , HUANG Xiao-ying , YAO Jin-guang , et al . Correlation between microRNA-24 expression and prognosis of aflatoxin B1-related hepatocellular carcinoma prognosis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(12) : 1743 . DOI: 11.3969/j.issn.1674-8115.2014.12.007
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