Review

Advances of serine starvation and p53 regulating oxidative stress of tumor cells

  • ZHANG Shuo ,
  • XU Bing-cong ,
  • CHEN Li-chang ,
  • et al
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  • Laboratory for Cell and Molecular Biology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China

Online published: 2014-12-30

Supported by

Undergraduate Innovation Program of Shanghai Jiao Tong University School of Medicine, 2013007

Abstract

Fast proliferation of tumor cells is characterized by energy metabolism abnormality that the major energy supply is glycolysis. The biosynthesis of tumor cells depends on serine. Serine starvation causes oxidative stress of tumor cells and activates p53 gene, which support the survival of tumor cells. The relationship between serine starvation and p53 gene provides new ideas for the metabolic targeted treatment of tumors. This paper reviews research progresses of regulating oxidative stress of tumor cells by serine starvation and p53.

Cite this article

ZHANG Shuo , XU Bing-cong , CHEN Li-chang , et al . Advances of serine starvation and p53 regulating oxidative stress of tumor cells[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(12) : 1839 . DOI: 11.3969/j.issn.1674-8115.2014.12.027

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