Journal of Shanghai Jiao Tong University (Medical Science) >

2015 , Vol. 35 >Issue 2: 262

DOI: https://doi.org/11.3969/j.issn.1674-8115.2015.02.022

Review

Research progresses of transcription factor CCAAT enhancer binding protein α

  • YING Ji ,
  • WANG Wei-ming
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  • Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2015-02-27

Supported by

National Natural Science Foundation of China, 81270782, 30771000; National Basic Research Program of China, 2012CB517701, 2012CB517604; the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period, 2011BAI10B00, 2011BAI10B06; Key Discipline Construction Project of Shanghai Municipal Commission of Health and Family Planning; National Key Clinical Specialist Construction Program of China, Health Industry Special Research Project, 201002010

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Abstract

CCAAT enhancer binding protein α (C/EBPα) is a member of CCAAT enhancer binding protein (C/EBP) family, which belongs to the basic region/zipper (bZIP) protein family. C/EBP family plays important roles in cell proliferation and differentiation, cell cycle regulation, immune responses, inflammatory reaction, energy metabolism, tumorigenesis, and tumor apoptosis. This paper reviews research progresses of the structure, expression regulation, and biology functions of C/EBPα.

Key words： CCAAT enhancer binding protein α; structure; expression regulation; biology function

Cite this article

YING Ji , WANG Wei-ming . Research progresses of transcription factor CCAAT enhancer binding protein α[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(2) : 262 . DOI: 11.3969/j.issn.1674-8115.2015.02.022

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