Review

Research progresses of regulation of alternative splicing

  • XU Gu-feng ,
  • ZHOU Cheng-liang ,
  • HUANG He-feng
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  • 1.Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China; 2.Department of Reproductive Endocrinology, International Peace Maternal and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2015-06-04

Abstract

Alternative splicing is an essential process to form mature mRNA by splicing introns from immature mRNA while keeping extrons. The abnormal alternative splicing plays an important role in the incidence and development of various diseases. This paper reviewed research progresses of mechanisms of incidence and regulation, and functions of alternative splicing, as well as the relationship between alternative splicing and diseases.

Cite this article

XU Gu-feng , ZHOU Cheng-liang , HUANG He-feng . Research progresses of regulation of alternative splicing[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(5) : 769 . DOI: 11.3969/j.issn.1674-8115.2015.05.028

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