Review

Advances of calcium/calmodulin-dependent protein kinase Ⅱin major depressive disorder

  • HUANG Yue-qi ,
  • PENG Dai-hui
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  • Division of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2015-09-30

Supported by

Fund of Science and Technology Commission of Shanghai Municipality,134119a6200; Shanghai Clinical Center for Mental Disorders,2014; National Key Clinical Disciplines at Shanghai Mental Health Center,Office of Medical Affairs, Ministry of Health, 2011-873

Abstract

Calcium/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) plays a crucial role in regulation of synaptic plasticity, glutamate receptors, and phosphorylation of cyclic adenosine phosphate response element binding protein (CREB), which are relevant to the major depressive disorder. This paper reviews possible mechanisms of CaMKⅡ in the process of major depressive disorder.

Cite this article

HUANG Yue-qi , PENG Dai-hui . Advances of calcium/calmodulin-dependent protein kinase Ⅱin major depressive disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2015 , 35(9) : 1389 . DOI: 10.3969/j.issn.1674-8115.2015.09.029

Outlines

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