In recent 30 years, Candida albicans has become the most common opportunistic pathogen that causes the incidence and mortality of patients with low immunity. With the frequent use of azole antifungal drugs, azole-resistant strains are often detected. Studies on the mechanism of drug resistance have drawn more and more attention. In recent years, studies on the mechanism of transcriptional regulation have also made great progress. The cis-acting elements and trans-acting factors of the resistant-related encoding gene were identified and the acting mechanism was partially elucidated. In this paper, research advances in the transcription regulation related to azole resistance of Candida albicans are reviewed.