Journal of Shanghai Jiao Tong University (Medical Science) >

2016 , Vol. 36 >Issue 6: 926

DOI: https://doi.org/10.3969/j.issn.1674-8115.2016.06.028

Review

Research advances in the roles of lipoxin in acute lung injury and its mechanisms

  • ZHANG Rong ,
  • ZHANG Yi-wei ,
  • WANG Yan ,
  • QI Ai-hua ,
  • WANG Li ,
  • WANG Ai-zhong
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  • Department of Anesthesiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2016-07-25

Supported by

National Natural Science Foundation of China, 81272147

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Abstract

Acute lung injury (ALI) and its severe phase, i.e. acute respiratory distress syndrome (ARDS), is a common critical disease characterized by noncardiac pulmonary edema and refractory hypoxemia with high mortality, which seriously threatens patients’ lives. As a potent endogenous counter-regulatory lipid mediator, lipoxin (LX) plays a key role in the pathogenesis of many diseases such as ALI/ARDS and becomes a research focus in recent years. This paper reviews research advances in the roles of LX in ALI/ARDS and its mechanisms.

Key words： lipoxin; acute lung injury; acute respiratory distress syndrome; inflammation; pro-resolution

Cite this article

ZHANG Rong , ZHANG Yi-wei , WANG Yan , QI Ai-hua , WANG Li , WANG Ai-zhong . Research advances in the roles of lipoxin in acute lung injury and its mechanisms[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(6) : 926 . DOI: 10.3969/j.issn.1674-8115.2016.06.028

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