With the expanding of human genome project and advent of post-genomic era, understanding of genome structure and function is more and more deepening. Increasing noncoding RNAs (ncRNAs) were discovered, among which longer than 200 nucleotides termed as long non-coding RNAs (LncRNAs) are involved in the pathophysiological processes including proliferation, differentiation, development, and apoptosis, becoming the new hot spots of cancer research. Breast cancer is the most common malignant tumor among women. In this article, the conception of LncRNAs and its role in occurrence, development and prognosis of breast cancer is reviewed.