Original article (Clinical research)

Relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus

  • WANG Ling-yan ,
  • YU Hao-yong ,
  • WEI Li
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  • 1. Department of Endocrinology and Metabolism, Shanghai Fengxian District Central Hospital, Shanghai 201400, China; 2. Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai 200233, China

Online published: 2017-03-30

Supported by

National Natural Science Foundation of China, 30670989

Abstract

Objective · To explore the relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus. Methods · Twenty-four patients undergoing elective abdominal surgery were enrolled, and were divided into normal glucose regulation-normal weight group (NGR-NW), normal glucose regulation-overweight/obesity group (NGR-OW/OB), and type 2 diabetic overweight/obesity group (T2DMOW/OB) according to the body mass index (BMI). The levels of chemerin and chemerinR mRNA were detected by reverse transcription PCR (RT-PCR). Results · Compare to the NGR-NW group, the chemerin mRNA levels of abdominal subcutaneous and omental fat were significantly increased in the NGR-OW/OB and T2DM-OW/OB group (P<0.05). Correlation analysis showed that the chemerin mRNA levels of abdominal omental fat were positively correlated with BMI, fasting insulin (FINS), triglyceride and serum chemerin (r=0.577, r=0.561, r=0.472, r=0.623, P<0.05 for all). The chemerin mRNA levels of abdominal subcutaneous fat showed significant positive correlation with BMI, FINS and serum chemerin (r=0.692, r=0.513, r=0.497, P<0.05 for all). Conclusion · The chemerin mRNA levels of abdominal subcutaneous and omental fat were positively correlated with BMI, FINS and serum chemerin, suggesting that the chemerin gene may play a crucial role in the pathophysiological mechanism of obesity and type 2 diabetes.

Cite this article

WANG Ling-yan , YU Hao-yong , WEI Li . Relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2017 , 37(3) : 352 . DOI: 10.3969/j.issn.1674-8115.2017.03.014

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