Building a professional clinical research team inside hospitals is in favor improving their research abilities, accelerating the clinical discipline construction, improving their comprehensive influence. Also it fits the objective of general hospital development under gate-keeping system. Now in domestic, the percentage of professional research staff in large hospitals accounts was much less than the international level. The main reasons included the misunderstanding of constructing the research-oriented hospitals, insufficient human resources enrollment, less attractive environment to the highlevel researchers and the absence of relevant degree training programs. To enhance the construction of research-oriented hospitals, it’s of key importance to build the professional research team in hospitals. Besides, the hospital has to update management conception, broaden the channels of talent cultivation, grasp the development of the subject accurately and interact with the basic medicine and public health subject, increase the financial investment and perfect the relevant management regulations.