Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization

  • DI Fang-fang ,
  • LIU Jian-sheng ,
  • LI Shang ,
  • DU Yan-zhi
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  • Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China

Online published: 2017-07-05

Supported by

Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152510

Abstract

 CCAAT/enhancer binding protein β (C/EBPβ) is a critical member of C/EBP family. C/EBPβ, based on the leucine zipper located in C terminal of the protein, can regulate transcriptional activities of downstream target genes involved in diverse cellular processes, such as proliferation and differentiation. Recently published studies have identified that C/EBPβ is essential in the decidualization of endometrial stromal cells. This review summarizes the roles and mechanisms of C/EBPβ during the courses of decidualization, which is aimed at providing novel insights for dysfunctional decidualization.

Cite this article

DI Fang-fang , LIU Jian-sheng , LI Shang , DU Yan-zhi . Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2017 , 37(6) : 865 . DOI: 10.3969/j.issn.1674-8115.2017.06.026

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