Original article (Clinical research)

Expression of MTA2 in endometrial carcinomas and its correlation with clinicopathological features

  • GAO Ling-tong ,
  • LIU Wei
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  • Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

Online published: 2018-03-09

Supported by

National Natural Science Foundation of China,81302253;Program of Shanghai Municipal Commission of Health and Family Planning,20124y081

Abstract

Objective · To explore the expression of MTA2 in endometrial carcinomas and its correlation with clinicopathological features.
Methods · The GCBI database was used to analyse the MTA2 expression in most cancers. Immunohistochemical staining of MTA2, p53, ER, PR and Ki-
67 was performed in 119 endometrial carcinomas tissues and 21 corresponding adjacent non-neoplastic endometria. And the correlation between MTA2
expression and clinicopathological characteristics was evaluated as well as the correlation between MTA2 expression and the expression of ER, PR, p53
or Ki-67. Results · The expression of MTA2 was up-regulated in most of the tumors including endometrial carcinomas in GCBI database. MTA2 was
overexpressed in endometrial carcinoma compared with the adjacent normal tissues (P=0.000),and the expression level was related to tumor grade
(χ2=8.072, P=0.018) and Ki-67 expression (r=0.227, P=0.013). Conclusion · MTA2 may act as an oncogene in endometrial carcinomas, and it is a promising target for diagnosis and treatment of endometrial carcinomas.

Cite this article

GAO Ling-tong , LIU Wei . Expression of MTA2 in endometrial carcinomas and its correlation with clinicopathological features[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(1) : 52 . DOI: 10.3969/j.issn.1674-8115.2018.01.009

Outlines

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