Journal of Shanghai Jiao Tong University (Medical Science) >

2018 , Vol. 38 >Issue 7: 797

DOI: https://doi.org/10.3969/j.issn.1674-8115.2018.07.015

Review

Mechanism of differences in prolactin levels in patients with schizophrenia after antipsychotics treatment

  • LI Yan-ge1 ,
  • YU Wen-juan1 ,
  • SHEN Yi-feng1 ,
  • LI Hua-fang2 ,
  • 3
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  • 1. Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China; 3. Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2018-07-30

Supported by

National Major Project for Investigational New Drug, 2018ZX09734-005; Multi-center Clinical Study Project of Shanghai Jiao Tong University School of Medicine, DLY201620; Project of Collaborative Innovation center for Translational Medicine at Shanghai Jiao Tong University School of Medicine,TM201624

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Abstract

Antipsychotics have been the mainstay of schizophrenia treatment, but the frequency of adverse reactions (ARs) related with antipsychotics usage is high. Of all the ARs, hyperprolactinemia is relatively common and the controversy over it remains ongoing, as different patients manifest different prolactin levels and different clinical syndromes. Into understand this heterogeneity, this review stated the mechanisms underlying the different prolactin levels in schizophrenia patients after antipsychotics treatment, including the ability to block dopamine D2 receptor (DRD2), the influence on blood-brain barrier permeability, varying affinity toDRD2, the inhibition/excitatory effect on DRD2andgeneticpolymorphisms.

Key words： prolactin; schizophrenia; antipsychotics

Cite this article

LI Yan-ge1 , YU Wen-juan1 , SHEN Yi-feng1 , LI Hua-fang2 , 3 . Mechanism of differences in prolactin levels in patients with schizophrenia after antipsychotics treatment[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(7) : 797 . DOI: 10.3969/j.issn.1674-8115.2018.07.015

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