Journal of Shanghai Jiao Tong University (Medical Science) >

2018 , Vol. 38 >Issue 9: 1027

DOI: https://doi.org/10.3969/j.issn.1674-8115.2018.09.005

Original article (Basic research)

Construction of a knowledge database of gene fusion and mutation in acute lymphoblastic leukemia

  • YAN Tian-qi1 ,
  • CHEN Li-wei2 ,
  • ZHU Yong-mei2 ,
  • LI Jian-feng2 ,
  • DAI Yu-ting2 ,
  • 3 ,
  • CUI Shu-Ya2 ,
  • JIANG Lu2 ,
  • CHEN Bing2 ,
  • HUANG Jin-yan2
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  • 1. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China; 2. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Online published: 2018-10-15

Supported by

National Natural Science Foundation of China, 81570122, 81770205; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20161303

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Abstract

Objective · To construct a database of fusion and mutation gene annotations for acute lymphoblastic leukemia (ALL) to assist genetic testing. Methods · ALL related gene annotations were collectedmining medical literature. The web server of the database was constructed based on Express framework, a NodeJS web application framework, and MySQL as the server-side development environment. Results · A total of 246 ALL-associated fusion and mutation gene entries were collected through programmed and manual text mining, including biological characteristics, clinical characteristics, clinical directions, target drugs and chemotherapeutic drugs. A web server of the ALL related gene knowledge database was established for convenient data management. Conclusion · In addition to the basic information about ALL related or potentially related genes, the database also involves clinical information which can be a reference tool for precision medicine of ALL.

Key words： acute lymphoblastic leukemia; gene fusion; gene mutation; knowledge database

Cite this article

YAN Tian-qi1 , CHEN Li-wei2 , ZHU Yong-mei2 , LI Jian-feng2 , DAI Yu-ting2 , 3 , CUI Shu-Ya2 , JIANG Lu2 , CHEN Bing2 , HUANG Jin-yan2 . Construction of a knowledge database of gene fusion and mutation in acute lymphoblastic leukemia[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2018 , 38(9) : 1027 . DOI: 10.3969/j.issn.1674-8115.2018.09.005

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