Objective · To explore the clinical characteristics and risk factors of male patients with psychotic disorders caused by alcohol. Methods · The clinical data of 52 male inpatients with alcohol use and related disorders treated in the Department of Addiction of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from May 2018 to December 2019 were collected. There were 19 cases of alcohol-induced psychotic disorder (alcohol-induced psychosis disorder, AIPD) group and 33 cases of non-AIPD group. The risk factors of AIPD were obtained by regression analysis. Results · AIPD patients had a higher incidence of hallucinations (47.4%) and delusions of murder (47.4%). Compared with non-AIPD groups, Logistic regression analysis of AIPD patients showed that vitamine B12 (VB12) serum level (P=0.011, OR=0.995) and total cholesterol serum level (P=0.039, OR=1.874) were associated with the occurrence of AIPD. Conclusion · Patients with AIPD have psychiatric symptoms mainly consisting of hallucinations and delusions of murder. When patients’ laboratory tests show abnormal serum VB12 and serum total cholesterol levels, attentions should be paid to the occurrence of AIPD.