Journal of Shanghai Jiao Tong University (Medical Science) >
Research progress in epigenetics of obsessive-compulsive disorder
Received date: 2020-04-17
Online published: 2021-02-28
Supported by
Outstanding Academic Leaders of Shanghai Health and Family Planning System(2017BR058);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20161321)
Obsessive-compulsive disorder is a high disabling psychiatric disease, with unknown etiology. Many studies have shown that the pathogenesis of obsessive-compulsive disorder is associated with both genes and the environment. Epigenetics has provided an approach to explaining the influence on individual inheritance caused by environmental factors. Nowadays, several types of research have proved that there are differences in DNA methylation between obsessive-compulsive disorder patients and healthy population, and the DNA methylation may be strongly related to treatment response. Additionally, an increased level of microRNA was found in patients with obsessive-compulsive disorder. This review summaries the studies of epigenetics of obsessive-compulsive disorder and concludes the possible changes in epigenetic modifications to further understand the pathophysiology of obsessive-compulsive disorder.
Key words： obsessive-compulsive disorder; epigenetics; genetics; DNA methylation; microRNA
Liang-jun LIN , Wei-di WANG , Pei WANG , Guan-ning LIN , Zhen WANG . Research progress in epigenetics of obsessive-compulsive disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(2) : 267 -272 . DOI: 10.3969/j.issn.1674-8115.2021.02.023
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