Journal of Shanghai Jiao Tong University (Medical Science) >

2021 , Vol. 41 >Issue 11: 1502 - 1508

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.11.015

Evidence-based medicine

Meta-analysis of the relationship between sleep duration and the risk of diabetic retinopathy

  • Jie LIU ,
  • Xin-min XIE ,
  • Xue-mei ZHI ,
  • Jing-yi LU
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  • 1.Shanghai Jiao Tong University School of Medicine Library, Shanghai 200025, China
    2.Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
LU Jing-yi, E-mail: lujingy1@126.com.

Online published: 2021-10-29

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Abstract

Objective

·To explore the relationship between sleep duration and the risk of diabetic retinopathy (DR) by performing a meta-analysis.

Methods

·The databases of Cochrane Library, PubMed, Embase, Web of Science, SinoMed, CNKI, VIP, and WanFang were searched for eligible studies regarding the relationship between sleep duration and the risk of DR up to April 2021. English search terms included "sleep" "sleep duration" "sleep time" "sleeping habit" "quantity of sleep diabetic retinopathy" and "retinal diseases". Chinese search terms included "睡眠" "睡眠时间" and "糖尿病性视网膜病变". The type of literature was observational studies, including cross-sectional studies, case-control studies, and cohort studies. Two researchers independently screened the literature and extracted data. The extracted data included the first author, country, publication time, study type, sample size, mean age, exposure assessment, sleep duration, outcome assessment, adjusted variables. The Newcastle-Qttawa Scale (NOS) was used to evaluate the quality of the included studies and a meta-analysis was performed by using R 4.0.4 software.

Results

·A total of 1 146 documents were retrieved, and 5 met the inclusion criteria, including 5 627 study subjects. Results showed that long sleep duration was positively correlated with the risk of any DR [the combined odds ratio(OR) in the fixed-effect model and random-effect model both were 2.05, 95% confidence interval (CI) 1.37?3.05) ], while short sleep duration was not associated with the risk of any DR (OR in the fixed-effect model and random-effect model were 0.89, 95%CI 0.72?1.10 and 0.98, 95%CI 0.71?1.37, respectively], but it was related to the risk of moderate DR (OR in the fixed-effect model and random-effect model were2.07, 95%CI 1.29?3.33 and 2.06, 95% CI 1.18?3.58, respectively). Short sleep duration was not associated with the risk of vision-threatening diabetic retinopathy (OR in the fixed-effect model and random-effect model both were 0.92, 95%CI 0.58?1.47).

Conclusion

·Sleep duration is significantly associated with the risk of DR, in which too much sleep is a risk factor, while short sleep is to be further determined by research. As a modifiable factor at the individual level, the role of sleep intervention in the management of DR should be further emphasized.

Key words： sleep duration; diabetic retinopathy; meta-analysis

Cite this article

Jie LIU , Xin-min XIE , Xue-mei ZHI , Jing-yi LU . Meta-analysis of the relationship between sleep duration and the risk of diabetic retinopathy[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(11) : 1502 -1508 . DOI: 10.3969/j.issn.1674-8115.2021.11.015

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