Journal of Shanghai Jiao Tong University (Medical Science) >

2021 , Vol. 41 >Issue 11: 1535 - 1539

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.11.021

Review

Review of non-invasive brain stimulation for the treatment of somatic symptoms in major depressive disorder

  • Lin-jie SHEN ,
  • Yu-xin HUANG ,
  • Yong WANG ,
  • Hua JIN
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  • Department of Outpatient, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
WANG Yong, E-mail: tianlai1977@yeah.net.

Online published: 2021-10-22

Supported by

Municipal Hospital Clinical Research Cultivation Project of Shanghai Shenkang Hospital Development Center(SHDC12018X24)

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Abstract

The somatic symptoms of major depressive disorder are related to the course of disease, remission rate and severity of clinical symptoms. At present, the first-line treatment is drug therapy, but the adverse effects of drugs often overlap with somatic symptoms. The studies have shown that non-invasive brain stimulation has application values in the treatment of somatic symptoms in major depressive disorder. This paper reviews the current status of repetitive transcranial magnetic stimulation and transcranial direct current stimulation in the treatment of somatic symptoms of major depressive disorder. It also discusses the efficacy of these two types of non-invasive brain stimulation techniques in the treatment of pain and insomnia in the patients with major depressive disorder, as well as the shortcomings of the existing research, and proposes the developing direction of future research.

Key words： non-invasive brain stimulation; major depressive disorder; somatic symptom; repetitive transcranial magnetic stimulation (rTMS); transcranial direct current stimulation (tDCS)

Cite this article

Lin-jie SHEN , Yu-xin HUANG , Yong WANG , Hua JIN . Review of non-invasive brain stimulation for the treatment of somatic symptoms in major depressive disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(11) : 1535 -1539 . DOI: 10.3969/j.issn.1674-8115.2021.11.021

References

1 World Health Organization. Depression and other common mental disorders: global health estimates[R/OL]. (2017-02-14) [2020-12-21]. .
2 Huang Y, Wang Y, Wang H, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2019, 6(3): 211-224.
3 Steinert C, Hofmann M, Kruse J, et al. The prospective long-term course of adult depression in general practice and the community. A systematic literature review[J]. J Affect Disord, 2014, 152/153/154: 65-75.
4 GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990?2015: a systematic analysis for the Global Burden of Disease Study 2015[J]. Lancet, 2016, 388(10053): 1545-1602.
5 Simon GE, VonKorff M, Piccinelli M, et al. An international study of the relation between somatic symptoms and depression[J]. N Engl J Med, 1999, 341(18): 1329-1335.
6 Zhou X, Peng Y, Zhu X, et al. From culture to symptom: testing a structural model of "Chinese somatization"[J]. Transcult Psychiatry, 2016, 53(1): 3-23.
7 Bekhuis E, Boschloo L, Rosmalen JG, et al. The impact of somatic symptoms on the course of major depressive disorder[J]. J Affect Disord, 2016, 205: 112-118.
8 Fang X, Zhang C, Wu Z, et al. The association between somatic symptoms and suicidal ideation in Chinese first-episode major depressive disorder[J]. J Affect Disord, 2019, 245: 17-21.
9 Zhao D, Wu Z, Zhang H, et al. Somatic symptoms vary in major depressive disorder in China[J]. Compr Psychiatry, 2018, 87: 32-37.
10 Freeman MP, Fava M, Gommoll C, et al. Effects of levomilnacipran ER on fatigue symptoms associated with major depressive disorder[J]. Int Clin Psychopharmacol, 2016, 31(2): 100-109.
11 Mowla A, Dastgheib SA, Razeghian Jahromi L. Comparing the effects of sertraline with duloxetine for depression severity and symptoms: a double-blind, randomized controlled trial[J]. Clin Drug Investig, 2016, 36(7): 539-543.
12 Fagiolini A, Florea I, Loft H, et al. Effectiveness of vortioxetine on emotional blunting in patients with major depressive disorder with inadequate response to SSRI/SNRI treatment[J]. J Affect Disord, 2021, 283: 472-479.
13 Sinyor M, Cheung CP, Abraha HY, et al. Antidepressant-placebo differences for specific adverse events in major depressive disorder: a systematic review[J]. J Affect Disord, 2020, 267: 185-190.
14 Woodham R, Rimmer RM, Mutz J, et al. Is tDCS a potential first line treatment for major depression?[J]. Int Rev Psychiatry, 2021, 33(3): 250-265.
15 Antal A, Alekseichuk I, Bikson M, et al. Low intensity transcranial electric stimulation: safety, ethical, legal regulatory and application guidelines[J]. Clin Neurophysiol, 2017, 128(9): 1774-1809.
16 Milev RV, Giacobbe P, Kennedy SH, et al. Canadian network for mood and anxiety treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 4.Neurostimulation treatments[J]. Can J Psychiatry, 2016, 61(9): 561-575.
17 Nikolin S, Alonzo A, Martin D, et al. Transcranial random noise stimulation for the acute treatment of depression: a randomized controlled trial[J]. Int J Neuropsychopharmacol, 2020, 23(3): 146-156.
18 Schecklmann M, Nejati V, Poeppl TB, et al. Bifrontal high-frequency transcranial random noise stimulation is not effective as an add-on treatment in depression[J]. J Psychiatr Res, 2021, 132: 116-122.
19 王红星, 王坤, 孙志超, 等. 经颅交流电刺激干预从未药物治疗的抑郁症患者的疗效初探[J]. 中华医学杂志, 2020, 100(3): 197-201.
20 Riddle J, Rubinow DR, Frohlich F. A case study of weekly tACS for the treatment of major depressive disorder[J]. Brain Stimul, 2020, 13(3): 576-577.
21 Haller N, Senner F, Brunoni AR, et al. Gamma transcranial alternating current stimulation improves mood and cognition in patients with major depression[J]. J Psychiatr Res, 2020, 130: 31-34.
22 Hett D, Rogers J, Humpston C, et al. Repetitive transcranial magnetic stimulation (rTMS) for the treatment of depression in adolescence: a systematic review[J]. J Affect Disord, 2021, 278: 460-469.
23 Sonmez AI, Kucuker MU, Lewis CP, et al. Improvement in hypersomnia with high frequency repetitive transcranial magnetic stimulation in depressed adolescents: preliminary evidence from an open-label study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2020, 97: 109763.
24 Antczak JM, Poleszczyk A, Wichniak A, et al. The influence of the repetitive transcranial magnetic stimulation on sleep quality in depression[J]. Psychiatr Pol, 2017, 51(5): 845-857.
25 Kaur M, Naismith SL, Lagopoulos J, et al. Sleep-wake, cognitive and clinical correlates of treatment outcome with repetitive transcranial magnetic stimulation for young adults with depression[J]. Psychiatry Res, 2019, 271: 335-342.
26 Nishida M, Kikuchi S, Nisijima K, et al. Actigraphy in patients with major depressive disorder undergoing repetitive transcranial magnetic stimulation: an open label pilot study[J]. J ECT, 2017, 33(1): 36-42.
27 Pellicciari MC, Cordone S, Marzano C, et al. Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep[J]. Front Hum Neurosci, 2013, 7: 433.
28 Phillips AL, Burr RL, Dunner DL. rTMS effects in patients with co-morbid somatic pain and depressive mood disorders[J]. J Affect Disord, 2018, 241: 411-416.
29 Zhang L, Zhu J, Zhang T, et al. Comparative efficacy of add-on rTMS in treating the somatic and psychic anxiety symptoms of depression comorbid with anxiety in adolescents, adults, and elderly patients: a real-world clinical application[J]. J Affect Disord, 2020, 276: 305-311.
30 Sekula LK, DeSantis J, Gianetti V. Considerations in the management of the patient with comorbid depression and anxiety[J]. J Am Acad Nurse Pract, 2003, 15(1): 23-33.
31 Antioch I, Ilie OD, Ciobica A, et al. Preclinical considerations about affective disorders and pain: a broadly intertwined, yet often under-explored, relationship having major clinical implications [J]. Medicina (Kaunas), 2020, 56(10): 504.
32 Bair MJ, Wu J, Damush TM, et al. Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients[J]. Psychosom Med, 2008, 70(8): 890-897.
33 Williams LS, Jones WJ, Shen J, et al. Outcomes of newly referred neurology outpatients with depression and pain[J]. Neurology, 2004, 63(4): 674-677.
34 Jaracz J, Gattner K, Jaracz K, et al. Unexplained painful physical symptoms in patients with major depressive disorder: prevalence, pathophysiology and management[J]. CNS Drugs, 2016, 30(4): 293-304.
35 O'Reardon JP, Fontecha JF, Cristancho MA, et al. Unexpected reduction in migraine and psychogenic headaches following rTMS treatment for major depression: a report of two cases[J]. CNS Spectr, 2007, 12(12): 921-925.
36 Hutka P, Krivosova M, Muchova Z, et al. Association of sleep architecture and physiology with depressive disorder and antidepressants treatment[J]. Int J Mol Sci, 2021, 22(3): 1333.
37 Ja??ová K, Albrecht J, ?ere?ňáková S, et al. Repetitive transcranial magnetic stimulation significantly influences the eating behavior in depressive patients[J]. Neuropsychiatr Dis Treat, 2019, 15: 2579-2586.
38 Woods AJ, Antal A, Bikson M, et al. A technical guide to tDCS, and related non-invasive brain stimulation tools[J]. Clin Neurophysiol, 2016, 127(2): 1031-1048.
39 Li MS, Du XD, Chu HC, et al. Delayed effect of bifrontal transcranial direct current stimulation in patients with treatment-resistant depression: a pilot study[J]. BMC Psychiatry, 2019, 19(1): 180.
40 Fregni F, El-Hagrassy MM, Pacheco-Barrios K, et al. Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation in neurological and psychiatric disorders[J]. Int J Neuropsychopharmacol, 2021, 24(4): 256-313.
41 Brunoni AR, Júnior RF, Kemp AH, et al. Differential improvement in depressive symptoms for tDCS alone and combined with pharmacotherapy: an exploratory analysis from the Sertraline vs. Electrical Current Therapy for Treating Depression Clinical Study[J]. Int J Neuropsychopharmacol, 2014, 17(1): 53-61.
42 Alonzo A, Chan G, Martin D, et al. Transcranial direct current stimulation (tDCS) for depression: analysis of response using a three-factor structure of the Montgomery-?sberg Depression Rating Scale[J]. J Affect Disord, 2013, 150(1): 91-95.
43 Mayur P, Howari R, Byth K, et al. Concomitant transcranial direct current stimulation with ultrabrief electroconvulsive therapy: a 2-week double-blind randomized sham-controlled trial[J]. J ECT, 2018, 34(4): 291-295.
44 Salehinejad MA, Ghanavai E, Rostami R, et al. Cognitive control dysfunction in emotion dysregulation and psychopathology of major depression (MD): evidence from transcranial brain stimulation of the dorsolateral prefrontal cortex (DLPFC)[J]. J Affect Disord, 2017, 210: 241-248.
45 Vigod SN, Murphy KE, Dennis CL, et al. Transcranial direct current stimulation (tDCS) for depression in pregnancy: a pilot randomized controlled trial[J]. Brain Stimul, 2019, 12(6): 1475-1483.
46 Mansour AG, Ahdab R, Khazen G, et al. Transcranial direct current stimulation of the occipital cortex in medication overuse headache: a pilot randomized controlled cross-over study[J]. J Clin Med, 2020, 9(4): 1075.
47 Yoo HB, Ost J, Joos W, et al. Adding prefrontal transcranial direct current stimulation before occipital nerve stimulation in fibromyalgia[J]. Clin J Pain, 2018, 34(5): 421-427.
48 Hassan AB, Danazumi MS, Abdullahi A, et al. Effect of transcranial direct current stimulation (tDCS) delivered via dorsolateral prefrontal cortex on central post-stroke pain and depression: a case report[J]. Physiother Theory Pract, 2021. DOI: 10.1080/09593985.2021.1891591.
49 Khedr EM, Omran EAH, Ismail NM, et al. Effects of transcranial direct current stimulation on pain, mood and serum endorphin level in the treatment of fibromyalgia: a double blinded, randomized clinical trial[J]. Brain Stimul, 2017, 10(5): 893-901.
50 陈依明. tDCS治疗抑郁障碍的起效及其睡眠症状的探索性研究[D]. 上海: 上海交通大学, 2020.
51 Zhou Q, Yu C, Yu H, et al. The effects of repeated transcranial direct current stimulation on sleep quality and depression symptoms in patients with major depression and insomnia[J]. Sleep Med, 2020, 70: 17-26.
52 Rezaei M, Shariat Bagheri MM, Ahmadi M. Clinical and demographic predictors of response to anodal tDCS treatment in major depression disorder (MDD)[J]. J Psychiatr Res, 2021, 138: 68-74.
53 Lefaucheur JP, Aleman A, Baeken C, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014?2018)[J]. Clin Neurophysiol, 2020, 131(2): 474-528.
54 Seminowicz DA, Moayedi M. The dorsolateral prefrontal cortex in acute and chronic pain[J]. J Pain, 2017, 18(9): 1027-1035.
55 Grimm S, Beck J, Schuepbach D, et al. Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder[J]. Biol Psychiatry, 2008, 63(4): 369-376.
56 Foster RG. Sleep, circadian rhythms and health[J]. Interface Focus, 2020, 10(3): 20190098.
57 Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation[J]. Brain, 2003, 126(pt 5): 1079-1091.
58 黄雨欣, 汤叶舟, 赵雅娟, 等. 经颅直流电刺激治疗单相和双相抑郁障碍的研究进展[J]. 上海交通大学学报(医学版), 2019, 39(12): 1460-1464.
59 Cheng W, Rolls ET, Ruan H, et al. Functional connectivities in the brain that mediate the association between depressive problems and sleep quality[J]. JAMA Psychiatry, 2018, 75(10): 1052-1061.
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