Journal of Shanghai Jiao Tong University (Medical Science) >

2021 , Vol. 41 >Issue 12: 1656 - 1660

DOI: https://doi.org/10.3969/j.issn.1674-8115.2021.12.016

Clinical research

Impulsive trait of patients with different subtypes of anorexia nervosa and its association with 5-hydroxytryptamine transporter gene-linked polymorphic region polymorphism

  • Li MEI ,
  • Jing ZHANG ,
  • Qing KANG ,
  • Cheng LIAN ,
  • Su-fang PENG ,
  • Shun-ying YU ,
  • Jue CHEN
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  • 1.Department of Clinical Psychology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2.Department of Psychiatry, Shanghai Huangpu Mental Health Center, Shanghai 200023, China
    3.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
CHEN Jue, E-mail: chenjue2088@163.com.

Online published: 2021-01-28

Supported by

National Natural Science Foundation of China(81771461);Important Disease Joint Research Project of Xuhui District Health and Family Planning Commission of Shanghai(XHLHGG201808);Shanghai Health System Important Weak Discipline Construction Plan(2019ZB0201);Project of Shanghai Clinical Research Center for Mental Health(19MC1911100)

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Abstract

Objective

·To explore the impulsive trait of patients with different subtypes of anorexia nervosa (AN) and its relationship with 5-hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) polymorphism.

Methods

·The patients with AN treated in the Clinical Psychosomatic Ward and Psychological Counseling Clinic of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from July 2013 to July 2018 were selected, including 76 patients with restricting type (AN-R group) and 81 patients with binge/pursing type (AN-BP group). The general situations, clinical characteristics and impulsive traits of the two groups were analyzed by General Situation Questionnaire, Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0) and Barratt Impulsivity Scale 11th Version (BIS-11), respectively. Quantitative real-time PCR was used to detect the 5-HTTLPR polymorphism of the two groups, and genotyping was performed.

Results

·Compared with AN-R group, the total score of EDE-Q 6.0 and its four subscales, the total score of BIS-11 and its three dimensions in AN-BP group were increased (all P<0.05). However, there was no significant difference in the distribution of 5-HTTLPR genotype and allele frequencies between the two groups. At the same time, there was no significant difference in the total score of BIS-11 and its three dimensions among AN patients with three 5-HTTLPR genotypes (S/S, S/L, L/L).

Conclusion

·AN-BP patients have more obviously impulsive traits than AN-R patients, but there is no correlation between two disease subtypes or impulsive traits and 5-HTTLPT polymorphism.

Key words： anorexia nervosa (AN); 5-hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR); polymorphism; impulsive trait

Cite this article

Li MEI , Jing ZHANG , Qing KANG , Cheng LIAN , Su-fang PENG , Shun-ying YU , Jue CHEN . Impulsive trait of patients with different subtypes of anorexia nervosa and its association with 5-hydroxytryptamine transporter gene-linked polymorphic region polymorphism[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2021 , 41(12) : 1656 -1660 . DOI: 10.3969/j.issn.1674-8115.2021.12.016

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