Journal of Shanghai Jiao Tong University (Medical Science) >

2022 , Vol. 42 >Issue 4: 490 - 495

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.04.011

Clinical research

Correlation between apnea hypopnea index and arteriosclerosis in patients with obstructive sleep apnea hypopnea syndrome complicated with hypertension

  • Biwen TANG ,
  • Yaya BAI ,
  • Yueliang HU ,
  • Huijuan CHAO ,
  • Qian WANG ,
  • Junli ZUO
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  • Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201801, China
ZUO Junli, E-mail: zjl12616@rjh.com.cn.

Received date: 2021-12-13

  Accepted date: 2022-04-18

  Online published: 2022-04-28

Supported by

Project of Shanghai Municipal Commission of Health and Family Planning(20184Y0100)

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Abstract

Objective

·To explore the effect of apnea hypopnea index (AHI) on arterial stiffness in patients of obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with hypertension.

Methods

·The patients admitted to Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, from July 2018 to December 2020 for polysomnography monitoring were enrolled, and divided into mild to moderate OSAHS group and moderate to severe OSAHS group according to AHI (5 times/h < AHI < 15 times/h or AHI≥15 times/h). Clinical and biochemical parameters were collected. 24-hour ambulate blood pressure and carotid-femoral pulse wave velocity (c-fPWV) were measured. Logistic regression analysis was performed between AHI and cardiovascular risk factors including age, body mass index (BMI), nocturnal systolic blood pressure, nocturnal diastolic blood pressure, low-density lipoprotein, fasting blood glucose, estimated glomerular filtration rate (eGFR), using of statin and hypoglycemic drugs.

Results

·A total of 365 patients were enrolled with an average age of (49.1±12.8) years. Three hundred and twenty-six (89.3%) were male and average BMI was (28.1±3.8) kg/m2. BMI, c-fPWV, fasting blood glucose and glycosylated hemoglobin (HbA1c) in moderate to severe OSAHS group (n=257) were significantly higher than those in mild to moderate OSAHS group (n=108)(P<0.05), and there was a significant positive correlation between AHI and c-fPWV (R2=0.047, P<0.001). In patients of OSAHS complicated with hypertension (n=291), c-fPWV, fasting blood glucose and HbA1c in moderate to severe OSAHS group (n=216) were significantly higher than those in mild to moderate OSAHS group (n=75) (P<0.05). After adjusting for age, BMI, AHI, nocturnal systolic blood pressure, nocturnal diastolic blood pressure, low density lipoprotein, fasting blood glucose, eGFR, medication of statin and hypoglycemic drugs, the Logistic regression model showed that AHI (OR=1.032, 95% CI 1.009?1.055, P=0.006), age (OR=1.078, 95%CI 1.021?1.138, P=0.007), and nocturnal systolic blood pressure (OR=1.058, 95% CI 1.010?1.109, P=0.017) were independent risk factors for c-fPWV elevation.

Conclusion

·Elevated AHI increases the risk of arterial stiffness in the patients of OSAHS complicated with hypertension.

Key words： obstructive sleep apnea hypopnea syndrome (OSAHS); pulse wave velocity; apnea hypopnea index (AHI); arterial stiffness

Cite this article

Biwen TANG , Yaya BAI , Yueliang HU , Huijuan CHAO , Qian WANG , Junli ZUO . Correlation between apnea hypopnea index and arteriosclerosis in patients with obstructive sleep apnea hypopnea syndrome complicated with hypertension[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022 , 42(4) : 490 -495 . DOI: 10.3969/j.issn.1674-8115.2022.04.011

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