Journal of Shanghai Jiao Tong University (Medical Science) >
Classification and research progress of corneal neurotization
Received date: 2021-10-26
Accepted date: 2022-04-19
Online published: 2022-04-28
Supported by
National Natural Science Foundation of China(81870688);Clinical Research Program of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine(JYLJ201818)
The corneal nerve originates from the trigeminal nerve, which mainly innervates the corneal sensation. Therefore, corneal nerve injury and decrease of corneal sensation occur when the trigeminal nerve is damaged. Neurotrophic keratopathy (NK) is a disease related with alterations in corneal nerves, leading to corneal epithelial defects, ulcer and perforation. However, mild NK is mostly manifested as a slight decrease in corneal sensation and instability of the tear film, so it is quite insidious in clinical practice. At the same time, the clinical treatment methods for promoting corneal reinnervation and restoring corneal sensation are usually relatively simple. Currently, medical treatment, non-surgical interventions and surgical interventions are the treatments for NK thus promoting corneal nerve and sensation recovery. In addition to maintaining the stability of the ocular surface, the main purpose of medical treatment is anti-infection and anti-inflammation, and to prevent further damage to the cornea. Novel biological agents are also under clinical trials such as platelet-rich plasma, autologous serum and recombinant human nerve growth factor. Non-surgical intervention which mainly includes therapeutic contact lenses, medical tape and botulinum toxin injections aims to reduce corneal exposure and protect the cornea. With regard to surgical interventions, in addition to the conventional procedures aimed at repairing corneal defects and reducing the exposed area, there is also a new procedure called corneal nerve transplantation, which is aimed at improving corneal sensation and corneal innervation. Corneal nerve transplantation is a new surgical method that is directly targeted at improving corneal sensation and innervation. It is an ideal surgical method for patients with loss of corneal subbasal nerve fibers due to trigeminal nerve injury. In conclusion, medical treatment, non-surgical intervention and surgical neurotization are not separated in clinical practice. This article summarizes the progress of the application of the above three types of treatments in order to provide a reference for the future clinical selection of appropriate treatment modalities and comprehensive reconstruction of corneal sensation according to the course and different severity of disease development.
Yue WU , Jiaying ZHANG , Wei WANG , Jin LI . Classification and research progress of corneal neurotization[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022 , 42(4) : 528 -534 . DOI: 10.3969/j.issn.1674-8115.2022.04.016
| 1 | DUA H S, SAID D G, MESSMER E M, et al. Neurotrophic keratopathy[J]. Prog Retin Eye Res, 2018, 66: 107-131. |
| 2 | BONINI S, RAMA P, OLZI D, et al. Neurotrophic keratitis[J]. Eye, 2003, 17(8): 989-995. |
| 3 | LAUNAY P S, GODEFROY D, KHABOU H, et al. Combined 3DISCO clearing method, retrograde tracer and ultramicroscopy to map corneal neurons in a whole adult mouse trigeminal ganglion[J]. Exp Eye Res, 2015, 139: 136-143. |
| 4 | LABETOULLE M, BAUDOUIN C, CALONGE M, et al. Role of corneal nerves in ocular surface homeostasis and disease[J]. Acta Ophthalmol, 2019, 97(2): 137-145. |
| 5 | AL-AQABA M A, DHILLON V K, MOHAMMED I, et al. Corneal nerves in health and disease[J]. Prog Retin Eye Res, 2019, 73: 100762. |
| 6 | DHILLON V K, ELALFY M S, AL-AQABA M, et al. Corneal hypoesthesia with normal sub-basal nerve density following surgery for trigeminal neuralgia[J]. Acta Ophthalmol, 2016, 94(1): e6-e10. |
| 7 | SACCHETTI M, LAMBIASE A. Diagnosis and management of neurotrophic keratitis[J]. Clin Ophthalmol, 2014, 8: 571-579. |
| 8 | LOCKWOOD A, HOPE-ROSS M, CHELL P. Neurotrophic keratopathy and diabetes mellitus[J]. Eye (Lond), 2006, 20(7): 837-839. |
| 9 | LUM E, MURPHY P J. Effects of ambient humidity on the cochet-bonnet aesthesiometer[J]. Eye (Lond), 2018, 32(10): 1644-1651. |
| 10 | ZHANG J Y, ZHAO Z L, SHAO C Y, et al. Degeneration of corneal sensation and innervation in patients with facial paralysis: a cross-sectional study using in vivo confocal microscopy[J]. Curr Eye Res, 2019, 44(11): 1209-1215. |
| 11 | KUGADAS A, GADJEVA M. Impact of microbiome on ocular health[J]. Ocul Surf, 2016, 14(3): 342-349. |
| 12 | NIWANO Y, IWASAWA A, AYAKI M. Ocular surface cytotoxicity and safety evaluation of tafluprost, a recently developed anti-glaucoma prostaglandin analog[J]. Ophthalmol Eye Dis, 2014, 6: 5-12. |
| 13 | GEERLING G, TAUBER J, BAUDOUIN C, et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction[J]. Invest Ophthalmol Vis Sci, 2011, 52(4): 2050-2064. |
| 14 | HOY S M. Ciclosporin ophthalmic emulsion 0.1%: a review in severe dry eye disease[J]. Drugs, 2017, 77(17): 1909-1916. |
| 15 | MIYAZAKI D, FUKUSHIMA A, OHASHI Y, et al. Steroid-sparing effect of 0.1% tacrolimus eye drop for treatment of shield ulcer and corneal epitheliopathy in refractory allergic ocular diseases[J]. Ophthalmology, 2017, 124(3): 287-294. |
| 16 | KOH K, JUN I, KIM T I, et al. Long-term results of topical 0.02% tacrolimus ointment for refractory ocular surface inflammation in pediatric patients[J]. BMC Ophthalmol, 2021, 21(1): 247. |
| 17 | PELLEGRINI M, SENNI C, BERNABEI F, et al. The role of nutrition and nutritional supplements in ocular surface diseases[J]. Nutrients, 2020, 12(4): 952. |
| 18 | GOMES J A P, AZAR D T, BAUDOUIN C, et al. TFOS DEWS Ⅱ iatrogenic report[J]. Ocul Surf, 2017, 15(3): 511-538. |
| 19 | SHTEIN R M, SHEN J F, KUO A N, et al. Autologous serum-based eye drops for treatment of ocular surface disease: a report by the American academy of ophthalmology[J]. Ophthalmology, 2020, 127(1): 128-133. |
| 20 | MANSOOR H, TAN H C, LIN M T Y, et al. Diabetic corneal neuropathy[J]. J Clin Med, 2020, 9(12): 3956. |
| 21 | HAHN J N, KAUSHIK D K, MISHRA M K, et al. Impact of minocycline on extracellular matrix metalloproteinase inducer, a factor implicated in multiple sclerosis immunopathogenesis[J]. J Immunol, 2016, 197(10): 3850-3860. |
| 22 | SOLEIMANI M, NADERAN M. Management strategies of ocular chemical burns: current perspectives[J]. Clin Ophthalmol, 2020, 14: 2687-2699. |
| 23 | DEEKS E D, LAMB Y N. Cenegermin: a review in neurotrophic keratitis[J]. Drugs, 2020, 80(5): 489-494. |
| 24 | CHAN C C, PROKOPICH C L. Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: overview of clinical trial program[J]. J Pharm Pharm Sci, 2019, 22(1): 49-56. |
| 25 | SOSNE G, RIMMER D, KLEINMAN H K, et al. Thymosin β 4: a potential novel therapy for neurotrophic keratopathy, dry eye, and ocular surface diseases[J]. Vitam Horm, 2016, 102: 277-306. |
| 26 | PFLUGFELDER S C, MASSARO-GIORDANO M, PEREZ V L, et al. Topical recombinant human nerve growth factor (cenegermin) for neurotrophic keratopathy: a multicenter randomized vehicle-controlled pivotal trial[J]. Ophthalmology, 2020, 127(1): 14-26. |
| 27 | FERRARI M P, MANTELLI F, SACCHETTI M, et al. Safety and pharmacokinetics of escalating doses of human recombinant nerve growth factor eye drops in a double-masked, randomized clinical trial[J]. BioDrugs, 2014, 28(3): 275-283. |
| 28 | BONINI S, LAMBIASE A, RAMA P, et al. Phase Ⅰ trial of recombinant human nerve growth factor for neurotrophic keratitis[J]. Ophthalmology, 2018, 125(9): 1468-1471. |
| 29 | BONINI S, LAMBIASE A, RAMA P, et al. Phase Ⅱ randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis[J]. Ophthalmology, 2018, 125(9): 1332-1343. |
| 30 | RIESTRA A C, ALONSO-HERREROS J M, MERAYO-LLOVES J. Platelet rich plasma in ocular surface[J]. Arch Soc Esp Oftalmol, 2016, 91(10): 475-490. |
| 31 | GIANNACCARE G, VERSURA P, BUZZI M, et al. Blood derived eye drops for the treatment of cornea and ocular surface diseases[J]. Transfus Apher Sci, 2017, 56(4): 595-604. |
| 32 | SONI N G, JENG B H. Blood-derived topical therapy for ocular surface diseases[J]. Br J Ophthalmol, 2016, 100(1): 22-27. |
| 33 | ALIO J L, RODRIGUEZ A E, ABDELGHANY A A, et al. Autologous platelet-rich plasma eye drops for the treatment of post-LASIK chronic ocular surface syndrome[J]. J Ophthalmol, 2017, 2017: 2457620. |
| 34 | WU X D, MA Y J, CHEN X, et al. Efficacy of bandage contact lens for the management of dry eye disease after cataract surgery[J]. Int Ophthalmol, 2021, 41(4): 1403-1413. |
| 35 | WABBELS B. Botulinum toxin-new developments in ophthalmology[J]. Klin Monbl Augenheilkd, 2018, 235(6): 721-724. |
| 36 | ERVIN A M, LAW A, PUCKER A D. Punctal occlusion for dry eye syndrome[J]. Cochrane Database Syst Rev, 2017, 6(6): CD006775. |
| 37 | TONG L, ZHOU L, BEUERMAN R, et al. Effects of punctal occlusion on global tear proteins in patients with dry eye[J]. Ocul Surf, 2017, 15(4): 736-741. |
| 38 | KIM B M, OSMANOVIC S S, EDWARD D P. Pyogenic granulomas after silicone punctal plugs: a clinical and histopathologic study[J]. Am J Ophthalmol, 2005, 139(4): 678-684. |
| 39 | CHI J J. Management of the eye in facial paralysis[J]. Facial Plast Surg Clin North Am, 2016, 24(1): 21-28. |
| 40 | KHOKHAR S, NATUNG T, SONY P, et al. Amniotic membrane transplantation in refractory neurotrophic corneal ulcers: a randomized, controlled clinical trial[J]. Cornea, 2005, 24(6): 654-660. |
| 41 | MANTELLI F, NARDELLA C, TIBERI E, et al. Congenital corneal anesthesia and neurotrophic keratitis: diagnosis and management[J]. Biomed Res Int, 2015, 2015: 805876. |
| 42 | GUHAN S, PENG S L, JANBATIAN H, et al. Surgical adhesives in ophthalmology: history and current trends[J]. Br J Ophthalmol, 2018, 102(10): 1328-1335. |
| 43 | ZEMBA M, STAMATE AC, TATARU C P, et al. Conjunctival flap surgery in the management of ocular surface disease (Review)[J]. Exp Ther Med, 2020, 20(4): 3412-3416. |
| 44 | DUA H S, OTRI A M, SAID D G, et al. The 'up-down' sign of acute ocular surface drug toxicity[J]. Br J Ophthalmol, 2012, 96(11): 1439-1440. |
| 45 | JONAS J B, RANK R M, BUDDE W M. Tectonic sclerokeratoplasty and tectonic penetrating keratoplasty as treatment for perforated or predescemetal corneal ulcers[J]. Am J Ophthalmol, 2001, 132(1): 14-18. |
| 46 | SAMII M. Modern aspects of peripheral and cranial nerve surgery//KRAYENBüHL H, BRIHAYE J, LOEW F, et al. Advances and technical standards in neurosurgery[M]. Vienna: Spinger, 1975: 33-85. |
| 47 | SAMII M. Reconstruction of the trigeminal nerve//SAMII M, JANNETTA P J.The cranial nerves[M]. Berlin: Springer, 1981: 352-358. |
| 48 | TERZIS J K, DRYER M M, BODNER B I. Corneal neurotization: a novel solution to neurotrophic keratopathy[J]. Plast Reconstr Surg, 2009, 123(1): 112-120. |
| 49 | ELBAZ U, BAINS R, ZUKER R M, et al. Restoration of corneal sensation with regional nerve transfers and nerve grafts: a new approach to a difficult problem[J]. JAMA Ophthalmol, 2014, 132(11): 1289-1295. |
| 50 | BAINS RD, ELBAZ U, ZUKER R M, et al. Corneal neurotization from the supratrochlear nerve with sural nerve grafts: a minimally invasive approach[J]. Plast Reconstr Surg, 2015, 135(2): 397e-400e. |
| 51 | BIGLIOLI F. Facial reanimations: part Ⅰ: recent paralyses[J]. Br J Oral Maxillofac Surg, 2015, 53(10): 901-906. |
| 52 | JACINTO F, ESPANA E, PADILLA M, et al. Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: a novel surgical technique[J]. Am J Ophthalmol Case Rep, 2016, 4: 14-17. |
| 53 | MALHOTRA R, ELALFY M S, KANNAN R B, et al. Update on corneal neurotisation[J]. Br J Ophthalmol, 2019, 103(1): 26-35. |
| 54 | CATAPANO J, FUNG S S M, HALLIDAY W, et al. Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation[J]. Br J Ophthalmol, 2019, 103(12): 1724-1731. |
/
| 〈 |
|
〉 |