Objective ·To investigate the current situation and problems of the construction of clinical research talents team in China, and propose targeted improvement strategies. Methods ·Self-designed questionnaires were made after literature review, expert interviews and two rounds of Delphi. An online questionnaire survey was conducted on 583 clinical research-related personnel from hospitals, biomedical enterprises, medical colleges and government departments in 27 provinces, cities and autonomous regions, and the survey results were analyzed. Results ·A total of 583 questionnaires were collected, 579 of which were valid, with an effective rate of 99.3%. The research results showed that: ① The lack of clinical research talents and the poor development environment of talents were the key factors restricting the high-level clinical research in China. ② Among the respondents, 72.7% of them were dissatisfied (very dissatisfied, dissatisfied and average) with the current training of clinical research talents. The main problems included lack of high-level research talents and a professional support team; the current performance evaluation system was monotonous, the salary and incentive were not profitable for clinical research, and medical personnel engaged in clinical research and support staff lacked promotion channels, etc. ③ The improvement strategies included systematically improving the clinical research ability of medical personnel, improving the clinical research training curriculum system, adopting different training methods in the school education stage and in-service education stage, and attaching more importance to the two teams′ training, clinical research physicians and clinical research methodology professionals. Conclusion ·Currently, it is urgent to expand the number of excellent medical students and improve the courses of clinical research methodology and relevant laws and regulations, encourage experienced research-oriented doctors to guide new staff in research projects, systematically improve the scientific research ability of current medical personnel, pay more attention to training of standardized implementation of clinical research projects, topic selection design and others, gather a high-level team of composite clinical research medical personnel, increase the amount of professionals in clinical research methodology, further attach importance to clinical research, and improve the development environment of clinical research talents from the aspects of professional title promotion, salary, scientific research evaluation, etc, so as to improve the level of clinical research in China.