Objective To investigate the efficacy and safety of hemicellulose dressing Veloderm^® for wound healing of donor sites of burn or reconstruction. Methods A randomized, open and controlled clinical trial was conducted. Hemicellulose dressing Veloderm^® (test group, n=24) and commonly used Vaseline gauze (positive parallel control)(control group, n=24) were applied to the donor sites of burn or reconstruction, respectively. The time of wound healing, and wound healing rates, cumulative healing rates and total effective rates 7 d after operation were compared between two groups, the adverse effects were observed, and the efficacy and safety of Veloderm^® for wound healing were evaluated. Results There was significant difference in the healing time of donor sites between test group and control group [(6.25±1.11) d vs (7.00±0.93）d, P<0.05]. The wound healing rate, cumulative healing rate and total effective rate 7 d after operation in test group were significantly higher than those in control group [(97.92±5.69)% vs (93.37±8.92)%, 87.50% vs 58.33%,100% vs 83.33%; P<0.05 for all]. There was no medicine-related adverse effect in both groups. Conclusion Hemicellulose dressing Veloderm^® is effective and safe for wound healing of donor sites of burn or reconstruction.