Journal of Shanghai Jiao Tong University (Medical Science) >

2011 , Vol. 31 >Issue 11: 1540

DOI: https://doi.org/10.3969/j.issn.1674-8115.2011.11.008

Monographic report (Bipolar disorder)

Research progress of immunological mechanisms of bipolar disorder

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  • Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China

Online published: 2011-11-29

Supported by

National Natural Science Foundation of China, 81000581, 30971047；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai Jiaotong University School of Medicine Foundation, 2008-6；Shanghai Mental Health Center Foundation, 2011-YJ-06

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Abstract

The pathogenesis of bipolar disorder has not been clearified. Heredity, neurotransmitter, neurotrophy, oxidative stress, immunology and environment have been reported to be related to the pathogenesis of bipolar disorder. Nowadays, the relationship between bipolar disorder and immunity has become the focus of attention. This review summarizes the immunity-related gene polymorphisms and cytokines in the pathogenesis of bipolar disorder, discusses the causal relationship between bipolar disorder and dysimmunity, and explore the application of immunity-related methods in the diagnosis and treatment of bipolar disorder.

Key words： bipolar disorder; immunology; cytokine

Cite this article

HONG Wu, FANG Yi-ru . Research progress of immunological mechanisms of bipolar disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2011 , 31(11) : 1540 . DOI: 10.3969/j.issn.1674-8115.2011.11.008

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