Multidrug-resistant Acinetobacter baumannii infection represents a growing problem in severe burns. The antimicrobial resistance mechanisms of Acinetobacter baumannii include an increasing arsenal of β-lactamases, altered expression of outer membrane protein, efflux pumps and biofilm formation. For Acinetobacter baumannii wound infection, silver sulfadiazine, sulfamylon and silver dressing are effective topical agents. The effective treatment with antibiotics in Acinetobacter baumannii sepsis involves polymyxins, sulbactam, minocycline and tigecycline, and the combination use of antibiotics is strongly recommended. Besides, some novel therapeutic agents for multidrug-resistant Acinetobacter baumannii are introduced in this paper.