Original article (Basic research)

Effect of 5-hydroxytryptamine on activity of bladder afferent nerves in rats

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  • Department of Physiology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China

Online published: 2012-11-05

Supported by

Shanghai Science and Technology Committee Foundation, 10ZR1417300

Abstract

Objective To investigate the effect of 5-hydroxytryptamine (5-HT) on the spontaneous and mechanosensitive activity of bladder afferent nerves. Methods The effects of intravesical instillation of different concentrations of 5-HT on the spontaneous and distension-induced pelvic afferent nerve activity were observed in the isolated rat bladder/pelvic nerve preparations. Results At rest, with the bladder empty, there was little background activity (<10 imp/s) in the pelvic nerve branch innervating the bladder. During ramp distension, the afferent nerve activity increased progressively as the intravesical pressure rose. Intraluminal instillation of 0.1 mL 5-HT (1 to 30 μmol/L) caused an increase of the ongoing afferent discharge and potentiated the low threshold (0-15 mmHg) mechanosensory responses in a concentration-dependent manner. Conclusion 5-HT directly activates low threshold bladder afferent fibers in the pelvic nerve, and can potentiate their mechanosensitivity.

Cite this article

SUN Qiao, SUN Bi-ying, LUO Ping, et al . Effect of 5-hydroxytryptamine on activity of bladder afferent nerves in rats[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2012 , 32(10) : 1292 . DOI: 10.3969/j.issn.1674-8115.2012.10.003

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