Journal of Shanghai Jiao Tong University (Medical Science) >

2013 , Vol. 33 >Issue 3: 354

DOI: https://doi.org/10.3969/j.issn.1674-8115.2013.03.020

Review

Research progress of relationship between mutations of insulin gene and diabetes mellitus

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  • 1.Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, the Sixth People´s Hospital, Shanghai Jiaotong University, Shanghai 200233, China； 2.Suzhou University, Suzhou 215006, China

Online published: 2013-03-29

Supported by

National Natural Science Foundation of China, 81270876, 30771022, 30971384； Shanghai Science and Technology Committee Foundation, 10XD1403400

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Abstract

Insulin is the unique hypoglycemic hormone which is secreted by islet β-cells. Insulin gene mutations could result in insulinopathies, permanent neonatal diabetes mellitus (PNDM), maturity onset diabetes of the young (MODY) and auto-antibodies-negative type 1 diabetes mellitus. The research progress of relationship between mutations of insulin gene and diabetes mellitus is reviewed in this article.

Key words： insulin gene; mutation; diabetes mellitus

Cite this article

LI Can, LIU Li-mei . Research progress of relationship between mutations of insulin gene and diabetes mellitus[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(3) : 354 . DOI: 10.3969/j.issn.1674-8115.2013.03.020

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