Original article (Clinical research)

Correlation of thrombelastogram with platelet aggregation rate and D-dimer in patients with acute cerebral infarction

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  • 1.Department of Hematology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China; 2.Department of Geriatrics, Chongming Branch of Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 202150, China

Online published: 2013-05-03

Supported by

Chongming County Science and Technology Committee Foundation, CK-2011-31

Abstract

Objective To investigate the correlation of parameters of thrombelastogram (TEG) with platelet aggregation rate (PAgT) and D-dimer in patients with acute cerebral infarction. Methods One hundred and two patients with acute cerebral infarction were selected, and were divided into mild acute cerebral infarction group (n=41), moderate acute cerebral infarction group (n=35) and severe acute cerebral infarction group (n=26) according to the scores of severity of neurological deficit. Besides, 50 healthy subjects were served as control group. All subjects were examined with the parameters of TEG (including R value, K value, α angle, MA value and CI value), PAgT and D-dimer. Results R-value and K value were significantly smaller, α angle, MA value and CI value were significantly larger and the D-dimer and PAgT levels were significantly higher in patients with acute cerebral infarction than in control group (P<0.01). The parameters of TEG and levels of PAgT and D-dimer in severe acute cerebral infarction group were significantly different from those in mild acute cerebral infarction group and moderate acute cerebral infarction group (P<0.05). The parameters of TEG and PAgT level in moderate acute cerebral infarction group were significantly different from those in mild acute cerebral infarction group (P<0.05), while there was no significant difference in D-dimer level between these two groups (P>0.05). Pearson correlation analysis revealed that the D-dimer and PAgT levels were positively related to α angle, MA value and CI level (P<0.01), and were negatively related to R-value and K value (P<0.01). Conclusion The parameters of TEG are significantly related to the D-dimer and PAgT levels in patients with acute cerebral infarction. TEG plays a role in the diagnosis of acute cerebral infarction, evaluation of severity of acute cerebral infarction and monitoring of hypercoagulable state.

Cite this article

ZHOU Xi-lin, LIANG Hui, HUANG Jie-jie . Correlation of thrombelastogram with platelet aggregation rate and D-dimer in patients with acute cerebral infarction[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(4) : 459 . DOI: 10.3969/j.issn.1674-8115.2013.04.016

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